We introduce the AbacusHOD model and present two applications of AbacusHOD and the AbacusSummit simulations to observations. AbacusHOD is an HOD framework written in Python that is particle-based, multi-tracer, highly generalized, and highly efficient. It is designed specifically with multi-tracer/cosmology analyses for next generation large-scale structure surveys in mind, and takes advantage of the volume and precision offered by the new state-of-the-art AbacusSummit cosmological simulations. The model is also highly customizable and should be broadly applicable to any upcoming surveys and a diverse range of cosmological analyses. In this paper, we demonstrate the capabilities of the AbacusHOD framework through two example applications. The first example demonstrates the high efficiency and the large HOD extension feature set through an analysis full-shape redshift-space clustering of BOSS galaxies at intermediate to small scales (<30Mpc/h), assessing the necessity of introducing secondary galaxy biases (assembly bias). We find strong evidence for using halo environment instead of concentration to trace secondary galaxy bias, a result which also leads to a moderate reduction to the "lensing is low" tension. The second example demonstrates the multi-tracer capabilities of the AbacusHOD package through an analysis of the extended Baryon Oscillation Spectroscopic Survey (eBOSS) cross-correlation measurements between three different galaxy tracers, LRGs, ELGs, and QSOs. We expect the AbacusHOD framework, in combination with the AbacusSummit simulation suite, to play an important role in a simulation-based analysis of the up-coming Dark Energy Spectroscopic Instrument (DESI) datasets.